Journal of Radiation and Cancer Research

CASE REPORT
Year
: 2021  |  Volume : 12  |  Issue : 4  |  Page : 190--193

A rare case of leiomyosarcoma of the prostate: Treatment and review of literature


Gopal Pemmaraju1, Sanjay Sharma2, Anand Parab1, Anuradha Singh1, Shubhangi Barsing1 
1 Department of Advanced Centre for Radiation Oncology, Dr. Balabhai Nanavati Hospital, Mumbai, Maharashtra, India
2 Mumbai Cancer Clinic, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Gopal Pemmaraju
Department of Advanced Centre for Radiation Oncology, Dr. Balabhai Nanavati Hospital, Mumbai, Maharashtra
India

Leiomyosarcoma is most common in adults and constitutes 38%–52% of primary prostatic sarcomas. Primary prostatic leiomyosarcoma is extremely rare which accounts for 0.1% of all prostatic malignancies. Patients present with signs and symptoms generally encountered with prostatic enlargement. A 41-year-old gentleman presented with complaints of burning micturition and difficulty in passing urine and stools for 1 month. Magnetic resonance imaging of the pelvis showed a 10 cm × 5.6 cm × 5.9 cm heterogeneous mass lesion originating from the prostate gland extending into bilateral seminal vesicles. There is loss of fat planes with bladder, rectum, and rectosigmoid. Transrectal ultrasound-guided biopsy and immunohistochemistry confirmed the diagnosis as leiomyosarcoma of the prostate. Because of the proximity of the prostate with urinary bladder and difficulty in resection, the patient received neoadjuvant stereotactic body radiotherapy (SBRT) to a dose of 30 Gy in 5 fractions alternate day over a period of 2 weeks. The patient underwent cystoscopy, followed by radical prostatectomy 1 month post-SBRT. Histopathological examination of the prostatectomy specimen was suggestive of high-grade spindle cell neoplasm. The margins were focally involved by the tumor. Because of positive margins, the patient underwent adjuvant radiation treatment to postoperative primary tumor bed to a dose of 30 Gy in 15 fractions by conventional fractionation on Halcyon 2.0. The patient tolerated the treatment well with minimal side effects. The patient is symptom-free and disease-free 3 months posttreatment and needs regular and long follow-up.


How to cite this article:
Pemmaraju G, Sharma S, Parab A, Singh A, Barsing S. A rare case of leiomyosarcoma of the prostate: Treatment and review of literature.J Radiat Cancer Res 2021;12:190-193


How to cite this URL:
Pemmaraju G, Sharma S, Parab A, Singh A, Barsing S. A rare case of leiomyosarcoma of the prostate: Treatment and review of literature. J Radiat Cancer Res [serial online] 2021 [cited 2022 May 16 ];12:190-193
Available from: https://www.journalrcr.org/article.asp?issn=2588-9273;year=2021;volume=12;issue=4;spage=190;epage=193;aulast=Pemmaraju;type=0