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  Indian J Med Microbiol
 

Figure 1: Representative hematoxylin and eosin stain images of adverse radiation effect from two separate patients (×200). (a) A left temporal lobe lesion sample from a 69-year-old with squamous cell cancer of the left parotid gland that metastasized to the brain who developed adverse radiation effect after facial external beam radiation and subsequent brain stereotactic radiosurgery. The patient's magnetic resonance scans are shown in Figure 2. A background of fibrinoid necrosis is seen with hyalinization of blood vessels (black arrows). Macrophages (blue arrows) that are scavenging necrotic debris are present. (b) A right occipital lobe brain lesion sample from a 72-year-old with lung adenocarcinoma previously treated with stereotactic radiosurgery. Three-month postprocedure, the patient developed symptomatic adverse radiation effect that was resected. The pathology slide shows a background of fibrinoid necrosis with hyalinization of blood vessels (black arrows) (×200)

Figure 1: Representative hematoxylin and eosin stain images of adverse radiation effect from two separate patients (×200). (a) A left temporal lobe lesion sample from a 69-year-old with squamous cell cancer of the left parotid gland that metastasized to the brain who developed adverse radiation effect after facial external beam radiation and subsequent brain stereotactic radiosurgery. The patient's magnetic resonance scans are shown in Figure 2. A background of fibrinoid necrosis is seen with hyalinization of blood vessels (black arrows). Macrophages (blue arrows) that are scavenging necrotic debris are present. (b) A right occipital lobe brain lesion sample from a 72-year-old with lung adenocarcinoma previously treated with stereotactic radiosurgery. Three-month postprocedure, the patient developed symptomatic adverse radiation effect that was resected. The pathology slide shows a background of fibrinoid necrosis with hyalinization of blood vessels (black arrows) (×200)